Javad–Carlo Scientific ResearchOS | Humboldt Fellowship Development

Humboldt Research Fellowship Call Opens Nov 15 (800 Cap) 18-Month Plan (Experienced Researcher)

Reproducibility and Perturbation Specificity of Genetic Regulatory Responses to DNA Damage in Human Immune Cells

Developing a competitive, high-impact fellowship application in statistical genetics at the Center for Human Genetics, Philipps-University Marburg. Combining primary human blood experimental procedures with advanced perturbation-eQTL interaction modeling and GWAS colocalization.

Applicant & Host Partnership

Dr. Javad Alizargar, MD, PhD

National Taipei University of Nursing & Health Sciences

PhD 2019 • Area D201 • Eligible (AvH)

PD Dr. Carlo Maj

Center for Human Genetics • Philipps-Univ. Marburg

Hosting Agreement & English Work Lang Confirmed

Dr. Javad Alizargar, MD, PhD

National Taipei University of Nursing & Health Sciences

PhD 2019 • Area D201 • Eligible (AvH)

PD Dr. Carlo Maj

Center for Human Genetics • Philipps-Univ. Marburg

Hosting Agreement & English Work Lang Confirmed

Discovered

796

Search Families

13/13

Candidate Topics

4 Topics

Host Endorsed

Topic A

Citation Graph

120 Edges

Target Donors

N = 70

Statistical Power

84.2%

Duration

18 Mos

Step 1: Evaluate & Endorse Topic

Compare the 4 candidate topics (Topic A: CD8+ DDR eQTLs, Topic B: TLR4 monocytes, Topic C: Dual perturbation, Topic D: Viability deconvolution). Carlo Maj has endorsed Topic A.

Step 2: Feasibility & Host Triage

Track laboratory feasibility in Marburg: Blood samples confirmed by Carlo Maj (Oct 8); radiation facility access and donor genotyping strategy pending final confirmation.

Step 3: Revise 18-Month Proposal

8-section proposal outline structured for the Experienced Researcher track (18 months, 3 split blocks). Features comment-driven AI revision with instant changelog recording.

Humboldt Application Scientific Gate Status

Call Countdown: Opens 15 November 2026

Gate 1: Host Eligibility & Track CONFIRMED

Experienced Researcher track (PhD 2019, <= 12 yrs, verified by AvH officer Vanessa Röber).

Gate 2: Literature Intelligence COMPLETED

All 13 search families populated, 796 papers indexed across PubMed, Europe PMC, and OpenAlex.

Gate 3: Topic Selection ENDORSED

Topic A endorsed by PD Dr. Carlo Maj (CD8+ T cell DDR eQTLs starting from blood).

Gate 4: Proposal Finalization IN PROGRESS

18-Month proposal draft ready; pending Carlo Maj review of specific work package milestones.

Host Collaborator Portal

PD Dr. Carlo Maj Review & Feasibility Triage Hub

A streamlined, zero-friction review station designed for Dr. Carlo Maj to confirm laboratory access in Marburg, review proposal sections, and guide the research design for the 15 November Humboldt fellowship submission.

Export Proposal (PDF) Export Proposal (DOCX)

Host Institutional Commitments Checklist (Center for Human Genetics, Marburg)

3 of 4 Formal Commitments Ready

1. Available Blood Samples

Host confirmed starting from available blood samples in Marburg so applicant experiences experimental workflow firsthand (Email Oct 8, 2026).

Confirmed Fact

2. Hosting Agreement

Carlo Maj confirmed provision of official AvH hosting agreement and designated research workplace (Email Nov 3, 2026).

Confirmed Fact

3. English Working Language

Carlo Maj confirmed English as the official working language for the research group and proposal submission (Email Nov 3, 2026).

Confirmed Fact

4. Core Facility Access

Scheduling radiation core access (1.5-2.0 Gy) vs. laboratory chemical radiomimetic Bleomycin.

Proposed Method

Interactive Laboratory Feasibility Triage

Carlo Maj can directly update parameter classifications and provide notes here.

Parameter	Category	Classification	Description	Host Guidance / Notes
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Official Regulations

Alexander von Humboldt Foundation Fellowship Guidelines

Programme Line for Experienced Researchers • Reference Code D201 • Nov 15 Call Cap Notice

1. Eligibility Criteria

Doctorate: Completed within the last 12 years (Javad completed PhD in 2019, 7 years ago • Eligible).
Position: Assistant Professor, Lecturer, or independent research group leader.
Independence: Evidence of independent research profile and PI role on competitive grants.
Mobility: No extensive stays in Germany in the 18 months prior to submission.

2. Duration & Split Stays

Total Duration: 6 to 18 months of fellowship funding.
Split Visits: May be divided into up to 3 separate stays lasting a minimum of 3 months each.
Timeframe: Stays must be completed within 36 months of beginning the first stay.
Monthly Stipend: €3,600 / month plus mobility allowances and health insurance subsidies.

3. Call System & Proposal Specs

Next Call Date: Opens 15 November 2026.
Volume Limit: First 800 applications only globally; early registration imperative.
Proposal Length: Approximately 5 pages maximum including bibliography.
Structure: State of research (~5 key citations), research questions, methods, and host fit.

Official Humboldt Selection Committee Evaluation Pillars

Part 1 • Canonical Reference

Confirmed Scientific Foundations & Experimental Mandate

Immutable baseline facts, host laboratory profile, and verified published literature benchmarks.

Proposed Host Laboratory (Marburg, Germany)

PD Dr. Carlo Maj is Head of Bioinformatics and Research Group Leader in Genetic Epidemiology at the Center for Human Genetics, Philipps-University Marburg. His group specializes in statistical genetics, exposure-eQTL mapping (Bigge et al. 2024), and computational functional genomics.

Confirmed Host Mandate: Primary blood handling (PBMC isolation, CD8+ T cell purification) in Marburg so applicant gains complete wet-lab procedure experience.

Confirmed Language: English is confirmed as working language.

Fellowship Applicant Profile

Dr. Javad Alizargar, MD, PhD is an Assistant Professor at the National Taipei University of Nursing and Health Sciences (NTUNHS), Taiwan. He completed his PhD in Taiwan in 2019 and serves as Principal Investigator on government-funded health research projects.

Humboldt Research Area: D201 – Medical Biometry, Epidemiology, Medical Informatics.

Formal Eligibility: Confirmed by Alexander von Humboldt Foundation on 22 Sept 2026.

Confirmed Published Benchmarks

1. DNA Damage Response e2QTL Benchmark

Bigge et al., BMC Genomics 2024 • DOI: 10.1186/s12864-024-11068-6

Identified context-dependent regulatory variants (exposure-eQTLs / e2QTLs) under genotoxic stress, demonstrating that genetic variants modulate apoptotic cascades.

2. Innate Immune Response eQTL Benchmark

Fairfax et al., Nature Communications 2014 • DOI: 10.1038/ncomms6236

Primary human monocytes under TLR4 activation across timepoints, mapping context-specific eQTLs to autoimmune disease susceptibility loci.

Reproducible Multi-API Literature Discovery

Structured Query Execution across PubMed, Europe PMC, and OpenAlex for all 13 Families

Search Family

Search Audit Trail (Zero Families with 0 Logs)

Date	Family	Source Engine	Query String	Retrieved	New Ingested
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Host–Applicant Scientific Discussion & Q&A Hub

Interactive Bilateral Q&A between Dr. Javad Alizargar and PD Dr. Carlo Maj • Ask Questions, Provide Answers, and Document Scientific Consensus

Bilateral Collaboration Active

Ask a Question or Post a Protocol Discussion Topic

Both applicant and host can comment and answer

Author Identity

Topic Type

Target Work Package

Question / Topic Title

Detailed Description & Context

Scientific Inquiries & Threaded Responses

Loading discussions...

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Javad–Carlo ResearchOS

Reproducibility and Perturbation Specificity of Genetic Regulatory Responses to DNA Damage in Human Immune Cells

Humboldt Application Scientific Gate Status

Candidate Research Topics & Host Alignment Board

PD Dr. Carlo Maj Review & Feasibility Triage Hub

Host Institutional Commitments Checklist (Center for Human Genetics, Marburg)

Interactive Laboratory Feasibility Triage

Alexander von Humboldt Foundation Fellowship Guidelines

Official Humboldt Selection Committee Evaluation Pillars

Confirmed Scientific Foundations & Experimental Mandate

Proposed Host Laboratory (Marburg, Germany)

Fellowship Applicant Profile

Confirmed Published Benchmarks

Reproducible Multi-API Literature Discovery

Search Audit Trail (Zero Families with 0 Logs)

Permanent Scientific Literature Library

Interactive Cytoscape Citation & Thematic Network

Selected Publication

Structured Evidence Registry

Adversarial Novelty Verification Engine

Completed Novelty Audits

Statistical Genetics Power Modeling & Lab Feasibility

Interaction-eQTL Statistical Power Calculator

Proposal Development Workspace (18-Month Modular Plan)

Summary of Changes & Revisions Log

Host–Applicant Scientific Discussion & Q&A Hub

Scientific Inquiries & Threaded Responses

Supported Scientific APIs & Public Data Repositories

Reproducibility and Perturbation Specificity of Genetic Regulatory Responses to DNA Damage in Human Immune Cells

Humboldt Application Scientific Gate Status

Candidate Research Topics & Host Alignment Board

Carlo Maj Topic Feedback & Endorsement

PD Dr. Carlo Maj Review & Feasibility Triage Hub

Host Institutional Commitments Checklist (Center for Human Genetics, Marburg)

Interactive Laboratory Feasibility Triage

Alexander von Humboldt Foundation Fellowship Guidelines

Official Humboldt Selection Committee Evaluation Pillars

Confirmed Scientific Foundations & Experimental Mandate

Proposed Host Laboratory (Marburg, Germany)

Fellowship Applicant Profile

Confirmed Published Benchmarks

Reproducible Multi-API Literature Discovery

Search Audit Trail (Zero Families with 0 Logs)

Permanent Scientific Literature Library

Interactive Cytoscape Citation & Thematic Network

Selected Publication

Structured Evidence Registry

Adversarial Novelty Verification Engine

Completed Novelty Audits

Statistical Genetics Power Modeling & Lab Feasibility

Interaction-eQTL Statistical Power Calculator

Proposal Development Workspace (18-Month Modular Plan)

Summary of Changes & Revisions Log

Host–Applicant Scientific Discussion & Q&A Hub

Scientific Inquiries & Threaded Responses

Supported Scientific APIs & Public Data Repositories